Texture-Based Analysis of Fetal Organs in Fetal Growth Restriction

Fetal growth restriction (FGR) is common, affecting around 10% of all pregnancies. Growth restricted fetuses fail to achieve their genetically predetermined size and often weigh <10th centile for gestation. However, even appropriately grown can be affected, with the diagnosis FGR missed before birth. Babies have a higher rate stillbirth, neonatal morbidity such as breathing problems, neurodevelopmental delay. usually due placental insufficiency leading poor perfusion fetal hypoxia. MRI increasingly used image fetus placenta. Here we explore use novel multi-compartment Intravoxel Incoherent Motion Model (IVIM)-based models analysis, improve understanding quantify abnormalities biomarkers in organs. In 12 normally gestational-age matched pregnancies (Median 28\(^{+4}\)wks±3\(^{+3}\)wks) acquired T\(_{2}\) relaxometry diffusion datasets. Decreased perfusion, pseudo-diffusion coefficient, blood values placenta liver were significant features distinguishing between normal controls (p-value <0.05). This may related preferential shunting away from brain that occurs insufficiency. These predict gestational age at delivery using simple machine learning models. Texture analysis was explored compare Haralick control fetuses, yielding most differences groups. project provides insights into effect on organs emphasizing impact placenta, potential an automated approach by leveraging